Search results for " muscle atrophy"

showing 3 items of 3 documents

Sonographische Verlaufskontrolle nach experimenteller Muskeldenervierung

2008

AIM: To describe sonographical results following acute, experimental muscle denervation. METHOD: Denervation of the supraspinatus and infraspinatus muscles was performed in 28 New Zealand white rabbits by segmental resection of the suprascapular nerve. The changes in the sonographic image of the muscles were follow up and documented at short intervals over 2 months. RESULTS: The sonographically detectable changes following denervation follow a definite pattern. In addition to the reduction in muscle diameter, sonographical signs of denervation include an increase of echodensity and an inhomogeneity of echotexture that appeared on day 14 after injury and became more prominent at larger inter…

DenervationMuscle Denervationbusiness.industrymedicine.medical_treatmentUltrasoundSkeletal muscleAnatomySuprascapular nervemedicine.anatomical_structuremedicineRadiology Nuclear Medicine and imagingNeurogenic muscle atrophySegmental resectionbusinessReduction (orthopedic surgery)Ultraschall in der Medizin
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Musashi-2 contributes to myotonic dystrophy muscle dysfunction by promoting excessive autophagy through miR-7 biogenesis repression

2021

Skeletal muscle symptoms strongly contribute to mortality of myotonic dystrophy type 1 (DM1) patients. DM1 is a neuromuscular genetic disease caused by CTG repeat expansions that, upon transcription, sequester the Muscleblind-like family of proteins and dysregulate alternative splicing of hundreds of genes. However, mis-splicing does not satisfactorily explain muscle atrophy and wasting, and several other contributing factors have been suggested, including hyperactivated autophagy leading to excessive catabolism. MicroRNA ( miR ) -7 has been demonstrated to be necessary and sufficient to repress the autophagy pathway in cell models of the disease, but the origin of its low levels in DM1 was…

autophagyMSI2 antisense oligonucleotides autophagy miR-7 muscle atrophy muscle dysfunction myotonic dystrophy myotubesRM1-950BiologyMyotonic dystrophyMSI2chemistry.chemical_compoundDrug DiscoverymedicineMyocyteGene silencingMBNL1muscle dysfunctionmyotonic dystrophyMyogenesisAutophagymiR-7Skeletal musclemedicine.diseaseMuscle atrophyCell biologymedicine.anatomical_structurechemistryMolecular MedicineTherapeutics. Pharmacologyantisense oligonucleotidesmedicine.symptomMolecular Therapy - Nucleic Acids
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Physiactisome: A New Nanovesicle Drug Containing Heat Shock Protein 60 for Treating Muscle Wasting and Cachexia.

2022

Currently, no commercially available drugs have the ability to reverse cachexia or counteract muscle wasting and the loss of lean mass. Here, we report the methodology used to develop Physiactisome—a conditioned medium released by heat shock protein 60 (Hsp60)—overexpressing C2C12 cell lines enriched with small and large extracellular vesicles. We also present evidence supporting its use in the treatment of cachexia. Briefly, we obtain a nanovesicle-based secretion by genetically modifying C2C12 cell lines with an Hsp60-overexpressing plasmid. The secretion is used to treat naïve C2C12 cell lines. Physiactisome activates the expression of PGC-1α isoform 1, which is di…

muscle atrophyProteomicsCachexiaexerciseArticle ; cachexia ; muscle atrophy ; exercise ; exosome ; muscle wasting ; sarcopeniamuscle wastingGeneral MedicineChaperonin 60ddc:sarcopeniaMuscular Atrophycachexia; muscle atrophy; exercise; exosome; muscle wasting; sarcopeniaQuality of LifeexosomeHumanscachexia; exercise; exosome; muscle atrophy; muscle wasting; sarcopeniaMuscle SkeletalCells
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